Symbol
Name
ID

Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
MGI:103013

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes

Single umbilical artery

Patent foramen ovale

Ventricular septal defect

Tetralogy of Fallot

Cardiomegaly

Patent ductus arteriosus

Pulmonary arterial hypertension

Prolonged QT interval

Shortened QT interval

J wave

Bradycardia

Sudden cardiac death

Atrial fibrillation

Ventricular tachycardia

Ventricular arrhythmia

Atrioventricular block

Syncope

Disease(s) Associated with CACNA1C

Brugada syndrome 3

Timothy syndrome

Mouse Phenotypes

patent ductus arteriosus

increased myocardial fiber size

heart right ventricle hypertrophy

increased heart weight

cardiac hypertrophy

dilated heart ventricle

internal hemorrhage

abnormal cardiac muscle contractility

decreased cardiac muscle contractility

abnormal fetal cardiomyocyte physiology

decreased heart rate

irregular heartbeat

abnormal myocardial fiber physiology

decreased calcium uptake by cardiac muscle

congestive heart failure

Availability

Mouse Genotype

Cacna1c^tm1.1Wac/Cacna1c^tm1.1Wac

Cacna1c^tm1Itl/Cacna1c^tm1Itl

Cacna1c^tm1Jst/Cacna1c^tm1Jst

Cacna1c^tm2.1Wac/Cacna1c^tm2.1Wac

Cacna1c^tm5.1Hfm/Cacna1c^tm5.1Hfm

Cacna1c^tm1Ggm/Cacna1c^tm1Ggm
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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